The Drug-Drug Interactions API provides information to determine the effect of a drug or a metabolite on another drug’s pharmacokinetic or pharmacodynamic profile.
It comprises a set of drug-drug interaction records supported by evidence from regulatory authorities and literature. Drug records for the general information on a drug and detailed reference records are also included. Four taxonomies to build drug queries are dedicated to this API: TherapeuticGroup, ProductCategory, MolecularMechanism and AdmeMechanism.
There are 2 types of drug-drug interactions depending on the cause of the interaction:
Each drug-drug interaction contains at least one associated interaction study. Each interaction study is defined as a drug-drug interaction in a given experimental condition and population. It is also associated with a given reference, model, outcome, potential adverse event(s) and risk. Drug-drug interaction drugs are those from the Drug Design API having at least one interaction study.
Drug-Drug Interactions API can help you to
Entities diagram (Colour coding – green: main entity | purple: supporting entities)
Search results and retrieve drug-drug interaction and drug records with supporting references. Search and browse different controlled vocabularies (ProductCategory, TherapeuticGroup, MolecularMechanism, AdmeMechanism).
Determine the effect of a drug or a metabolite on another drug’s pharmacokinetic or pharmacodynamic profile. Drug-drug interaction records are supported by evidence from regulatory authorities and literature. To access this demo, click the “DDI” link on the top of the page once authenticated.
APIs involved in this demo: Drug-Drug Interactions API and Targets API for drug details and related clinical trials Ids (JSME molecule editor for drug rendering). Ability to access the clinical trial summary and details using the Clinical API.
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