Targets

The Targets API exposes a new target concept created by combining Integrity and MetaCore contents.

The new target records contain Gene, RNA and Protein information. Target-drug-condition / target-gene-condition / target-gene variant-condition associations are also accessible.

Targets API can help you to

  • Combine proprietary data to build a comprehensive resource giving more confidence that everything known in the organization is displayed
  • Stay up to date with all the latest drug targets' information to facilitate better and faster business- critical decisions

Content

  • Information on targets from patents, journals, meetings, trial registries, websites, regulatory bodies and public databanks
  • Details, including chemical structures of compounds known to interact with the target
  • Associated drugs with phase of development for each condition
  • Associated variant and biomarker information

Entities diagram (Colour coding – green: main entity | purple: supporting entities)

Search results, retrieve and export target records; Retrieve interactions, sequences, condition-drug / condition-gene / condition-gene variant associations related to a given target; Retrieve drug, trial, patent and reference records; Search and browse different controlled vocabularies (TargetClassification, Condition, Localization, Tissue, CellLine, Fluid).

 

Demos 
 Demo Video

Target records combine information from Integrity and MetaCore. They contain gene, RNA and protein information as well as relevant target-condition association (drug, gene, gene-variant) among other data.

APIs involved in this demo: Targets API to access target details as well as related drugs / biomarkers / variants / interactions, Drug Design API to access pharmacology results. Ability to access clinical trial details for drugs related to a given target via the Clinical API. Clarivate Analytics information is combined with public data thanks to the ChEMBL API.

 Demo Video

This Pipeline Pilot protocol  takes all the targets of the drugs from immuno-oncology trials and creates a report for each Target. The reports show the target summary from the Targets API and an active drug summary for each condition (from Drug Design API) the target is associated with.
Note: 1596 in the query corresponds to Immunomodulator.

APIs involved in this demo: Clinical, Drug Design and Targets APIs.

Indication-centric infographic.

APIs involved in this demo: Investigational Drugs API to access drugs, companies and deals, Clinical API to access trials, conferences, press release and literatures (articles), Ontologies API for the indications and indication synonyms, Patents and Targets APIs.

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