Clinical

The Clinical API provides access to manually curated information on worldwide clinical trials from 24 major trial registries (covering drugs, biologics, devices and biomarkers), press releases (from 1987 to date), conference abstracts and reports (from 2007 to date). It includes access to clinical literature (from 1964 to date – structure searchable) based on Derwent Drug File (DDF) data.

Each entry provides a protocol report, an outcomes report (where appropriate) and all associated links to drugs (for both the interventions & controls in the trial), drug classes and actions, companies (sponsors and collaborators of the trial), inclusion and exclusion criteria, supporting references (including reports from conferences and abstracts), and other trial records where there are specific trial-trial relationships. Please see the Clinical API 2.0-FAQ for more details.

Clinical API can help you to

  • Stay up to date with the latest clinical trial information and get to the data quickly
  • Be confident the results returned reveal the most up-to-date trial outcomes and adverse event information
  • Inform your trial design by obtaining completive intelligence about other trials, what sponsors are running them, how they are designed, what drugs are used
  • Perform cross trial analysis using drugs used and their mechanisms, biomarkers, outcomes and adverse events
  • Match complete company, drug and biomarker information from other Cortellis APIs to inform and broaden your analysis
  • Match patients to trials programmatically using drugs, recruitment status, indication, gene variants, inclusion and exclusion criteria

Content

  • Clinical trial content from international registry sources
    • Registries received through feed: CT.gov, EudraCT (EU), UMIN (Japan), ISRCTN (global), ANZCTR (Australia, New Zealand), IRCT (Iran), NTR (Netherlands), HKCT (Hong Kong CTR) and DRKS (Germany)
    • Registries captured manually: ChiCTR (China), JapicCTI (Japan), CTRI (India), CRiS (Korea), NMRR (Malaysia), HSA CTR (Singapore), JMACCT CTR (Japan), ReBec (Brazil), PHRR (Philippines), TCTR (Thailand), SRM CTR (Russia), Mexico CTR (Mexico), SLCTR (Sri Lanka), PACTR (Pan African), RPCEC (Cuba) and UKCRN (UK – coverage halted as of late 2016)
  • Summaries of selected journal articles (DDF)
  • Trial outcomes derived from journals, conferences and press releases
  • Pharmaceutical company press releases and information from major conferences

Entities diagram (Colour coding – green: main entities | purple: supporting entities)

Search results, retrieve and export trial (including sites), press release, conference and clinical literature records. Search and browse different controlled vocabularies (endpoints, patient segment, exclusion criteria, inclusion criteria, companiesSponsor, companiesCollaborator, trialCompanies, category).

 

Demos 
 Demo No Video

Search and browse clinical trials, literature, biomarkers and drug records as well as link through to original articles via Web of Science and to compare many trials side-by-side. Some records have associated epidemiology data.

APIs involved in this demo: Clinical, Ontologies and Investigational Drugs APIs to access drug details and Biomarkers API to access biomarker use and biomarker details.

 Demo Video

This Pipeline Pilot protocol finds commercially significant trials for the chosen indication (Melanoma by default) where biomarkers are captured for the trial. The first 5 trials will be listed in summary form.

Clicking the hyperlinked trial ID will display a biomarker trial report. This report displays a biomarker summary for each biomarker in the trial in addtion to the first 5 biomarker use records for each biomarker.

APIs involved in this demo: Clinical and Biomarkers APIs.

 Demo No Video

A generic Pipeline Pilot protocol searching for Clinical literature references. The results are returned (but limited) in a citation-like format.
A click on a title opens the corresponding literature record.

API involved in this demo: Clinical API.

 Demo Video

This Pipeline Pilot protocol  takes all the targets of the drugs from immuno-oncology trials and creates a report for each Target. The reports show the target summary from the Targets API and an active drug summary for each condition (from Drug Design API) the target is associated with.
Note: 1596 in the query corresponds to Immunomodulator.

APIs involved in this demo: Clinical, Drug Design and Targets APIs.

 Demo Video

This Pipeline Pilot protocol finds immuno-oncology clinical trials for the chosen indication. Each trial charts adverse events and trial report and a series of graphs shows adverse events and drugs across the all the matching trials.
Note: 1596 in the query corresponds to Immunomodulator.

APIs involved in this demo: Clinical, Investigational Drugs APIs.

 Demo No Video

A generic Pipeline Pilot protocol searching for Clinical trials. The results are returned (but limited) in a simple table format.

A click on a row opens the corresponding trial record.

API involved in this demo: Clinical API.

For a given indication, retrieve drugs from Investigational Drugs API. For a the selected drugs, find trial results from the Clinical API, drill down to trial records that may be combined with data from Regulatory API.

APIs involved in this demo: Investigational Drugs, Clinical and Regulatory APIs.

Indication-centric infographic.

APIs involved in this demo: Investigational Drugs API to access drugs, companies and deals, Clinical API to access trials, conferences, press release and literatures (articles), Ontologies API for the indications and indication synonyms, Patents and Targets APIs.

A visual search interface for clinical trials. Results are displayed using charts and diagrams which can be used to refine them.

API involved in this demo: Clinical API.

Cortellis Labs Terms & Conditions

The following terms govern your use of Cortellis Labs apps:

  1. Clarivate Analytics does not provide support for Cortellis Labs apps. We suggest you direct any questions regarding your use be directed to the discussion groups.
  2. THIS SITE IS PROVIDED BY CLARIVATE ANALYTICS ON AN "AS IS" AND "AS AVAILABLE" BASIS. CLARIVATE ANALYTICS MAKES NO REPRESENTATIONS OR WARRANTIES OF ANY KIND, EXPRESS OR IMPLIED, AS TO THE OPERATION OF THIS SITE, OR THE INFORMATION, CONTENT OR MATERIALS INCLUDED ON THIS SITE. YOU EXPRESSLY AGREE THAT YOUR USE OF THIS SITE IS AT YOUR SOLE RISK.
  3. The privacy notice applies to your use of Cortellis Labs apps, including our use of Google Analytics for site optimization and demo usage statistics.