The Drug Design API provides information on bioactive compounds from patents through to launched products including experimental pharmacology/pharmacodynamics, pharmacokinetics/metabolism results.
Drugs & Biologics
Compounds are those with a pharmacologic activity and relevance as potential therapeutics or diagnostics in humans. Each compound record is indexed with links to references, patents and other content types. Compounds must show potential pharmacological activity (biological testing, preclinical or clinical studies). Compounds require only minimal information for inclusion – name/definition or structure, organization and therapeutic indication.
This content includes chemical entities, natural extracts, drugs with undisclosed structure / description, drug delivery systems, technologies, drug combinations, biological / biotechnology products, vaccines, dietary supplements, some bio-similars / follow-on biologics. It excludes delivery systems, kits / assays, medical devices and over-the-counter (OTC) products.
A pharmacology result provides experimental assays/studies where the pharmacological effect of a drug/compound have been evaluated, either in vivo, in vitro or ex vivo. Data cover any biological system (cellular cultures, microorganisms, tissue baths, animals and humans) and results are provided with detailed pharmacological parameters, expressing potency, efficacy and/or effectiveness, preferably from dose-response studies. Where an experimental assay does not detail exact values or parameters, they are not included in the content.
Each experimental pharmacology result includes experimental quantitative data obtained from the studies evaluating the pharmacological effects and are aimed at defining the drugs pharmacological profile, including action on biological target, therapeutic and toxicological effects.
Pharmacokinetic data are captured where reported and measured PK/ADME results are available within our source data. Each pharmacokinetic result contains the reported numeric value for an individual evaluated pharmacokinetic parameter, expressed with specific units.
Pharmacokinetic studies covered are those performed in vivo: in animals (preclinical studies) and in humans (clinical studies). The pharmacokinetic result contains all the salient information regarding the experiment, including critical pharmacokinetic outputs such as, area under the curve (AUC), half-life (t1/2), clearance, etc. and these are all filterable to allow users to identify e.g. all AUC results for a given drug/drug type.
Each experiment is detailed with both the measured and administered products, formulation type, dosage concentration and the administration route. These are all clearly identifiable within the experiment and can be searched or filtered to allow direct comparison between drugs/experiments.
Exceptions to this content include in vitro studies where the details of the model are not provided (animal or human), results published without specifying the administered dose, units etc. or results from patents.
Disease reports are created for:
This content set excludes diseases and conditions for which no products are under active development at this time.
Drug Design API can help you to
Entities diagram (Colour coding – green: main entities | purple: supporting entities)
Search results by text and/or structure (exact, similarity, substructure) on the experimental pharmacology or pharmacokinetics domains and retrieve the supporting patents and references. Search results by text and/or structure and retrieve drug records (including molfiles and images). Search and retrieve disease briefing records.
Access to information (structure searchable) on bioactive compounds from discovery (patents/references) through to launched drugs.
APIs involved in this demo: Drug Design API, Target API and Clinical API to access to trials with possible links to Targets API.
To access this demo, click the “Drugs” link on the top of the page once authenticated.
This Pipeline Pilot protocol takes all the targets of the drugs from immuno-oncology trials and creates a report for each Target. The reports show the target summary from the Targets API and an active drug summary for each condition (from Drug Design API) the target is associated with.
Note: 1596 in the query corresponds to Immunomodulator.
APIs involved in this demo: Clinical, Drug Design and Targets APIs.
This demo answers the questions:
API involved in this demo: Drug Design API.
The following terms govern your use of Cortellis Labs apps: